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Wet AMD: Press Kit

Neovascular AMD

Age-related macular degeneration (AMD) is a leading cause of blindness in people over the age of 50, and neovascular AMD, also known as wet AMD, is a particularly severe form of the disease. Preclinical animal models play a crucial role in understanding the disease pathology, testing novel therapies, and translating the findings to clinical trials. At MediNect Bioservices, we specialize in preclinical research for neovascular AMD, and we have a range of well-established models designed to mimic the key features of human nAMD that allow us to study the efficacy of potential therapeutics.

Our models exhibit hallmark features of choroidal neovascularization (CNV), such as angiogenesis, vascular leakage, inflammation, and subretinal fibrosis and are validated for efficacy testing of various therapeutic modalities. Our expert team of scientists can also tailor custom models to meet specific research needs. Our models include:

  • Choroidal neovascularization (CNV) model: This model involves inducing the growth of new blood vessels in the choroid layer of the eye, which can invade the overlying retina and cause vision loss. The CNV model is a well-established and widely used model for studying neovascular AMD, as it allows researchers to test the efficacy of potential therapeutics in preventing or treating abnormal blood vessel growth.

  • Two-stage laser CNV model: This model involves creating two separate laser-induced injuries in the retina, which lead to the growth of abnormal blood vessels and sustained vascularised fibrotic lesion. This model is particularly useful for studying the effects of therapeutics targeting later stages of the disease.

  • Oxygen-induced retinopathy (OIR) model: This model involves exposing neonatal mice to alternating levels of oxygen, which can disrupt the normal development of blood vessels in the retina and lead to the growth of abnormal blood vessels. The OIR model is a widely used model for studying retinal neovascularization, and it is particularly relevant to neovascular AMD research.

  • Retinal vein occlusion (RVO) model: This model involves blocking the retinal vein, which can lead to the growth of abnormal blood vessels in the retina. RVO is a common cause of neovascular AMD, and this model allows researchers to study the underlying mechanisms of RVO and test potential therapeutic interventions.

  • Genetic models: We also offer certain genically altered animal models that mimic certain features of disease. 

 

Age-related macular degeneration (AMD) is a leading cause of blindness in people over the age of 50, and neovascular AMD, also known as wet AMD, is a particularly severe form of the disease. At MediNect Bioservices, we specialize in preclinical research for neovascular AMD, and we have a range of well-established models that allow us to study the efficacy of potential therapeutics.

Fluorescein angiography is a non-invasive imaging technique used to assess the blood flow and vascular structure of the retina in preclinical animal models. The technique involves the injection of a fluorescent dye, such as fluorescein, into the systemic circulation of the animal. The dye then circulates to the retina, where it highlights the retinal vasculature under fluorescent light.

The outputs provided by fluorescein angiography can be used provides an assessment of retinal blood flow and vascular structure in preclinical models of diabetic retinopathy. It is a good tool to evaluate the efficacy of potential therapies by comparing pre- and post-treatment images on the extent of vascular damage, such as areas of leakage, occlusion, or neovascularisation.

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