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Oxygen-induced Retinopathy model

Mouse and Rat

Background: The OIR model is based on the response of the retinal blood vessels to varying oxygen levels. It simulates conditions in premature infants, where fluctuating oxygen levels can lead to abnormal retinal vascular growth.

Process: In this model, newborn mice or rats are exposed to high oxygen levels, causing initial vessel loss in the retina. Upon return to normal oxygen levels, there's a rapid and excessive growth of abnormal blood vessels, mimicking the pathological process seen in humans.

Applications: We offer the OIR model to investigate your MoA, test the efficacy of your therapeutic, and explore potential therapeutic strategies. It's the quickest and most robust model to investigate angiogenesis.

Streptozotocin (STZ) Model

Mouse and Rat

Background: The Streptozotocin (STZ) Model is used to simulate Type 1 diabetes-induced retinopathy in rodents, offering insights into the early stages of diabetic retinopathy.

Process: In this model, STZ, a compound toxic to insulin-producing pancreatic cells, is administered to induce hyperglycemia in rodents, mimicking Type 1 diabetes. The hyperglycaemia induces early diabetic retinopathy features, such as microvascular damage.

Applications: We offer the STZ model for clients looking to learn more about their MoA targeting diabetic microvascular and also efficacy Studies to assess the effect of their therapeutic.


  • Does not effectively model Type 2 diabetes.

  • Less suitable for studying advanced stages of retinopathy.

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